Regulation of T cell costimulation

Across TCGA patient cohorts, RNA activity of the Regulation of T cell costimulation pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRBV20-1, FGR, and MIR4420, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of T cell costimulation activity versus TRBV20-1 in HNSC (Pearson r = 0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	TRBV20-1 →	+1.449	+1.048	.001	.001	3	5
HNSC	FGR →	+1.129	+1.106	<.001	<.001	3	5
GBM	MIR4420 →	+1.187	+0.859	<.001	<.001	3	5
HNSC	TRBV6-6 →	+0.904	+0.913	.005	.003	3	5
GBM	CD40 →	+0.749	+1.036	.004	<.001	3	4
BRCA	POLI →	-0.705	-0.450	.001	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000523 vs TRBV20-1 — HNSC

Explore this scatter interactively →