Regulation of T cell costimulation

Across TCGA cell cohorts, RNA activity of the Regulation of T cell costimulation pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC25A4, CD46, and ERO1B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC25A4 grouped by Regulation of T cell costimulation-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SLC25A4 →	-1.216	-1.111	.003	.006	3	4
PANCREAS	CD46 →	-1.069	-1.524	.001	.003	3	4
OVARY	ERO1B →	+1.104	+1.372	.003	<.001	3	3
SKIN	PRKCI →	+0.798	+1.589	.005	<.001	3	3
BREAST	ZSCAN22 →	+0.318	+0.718	.008	.002	3	3
BONE	SEMA3D →	+1.814	+1.477	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC25A4 by Regulation of T cell costimulation activity — SKIN

Explore this box plot interactively →