"Positive regulation of CD4-positive, alpha-beta T cell activation"

Across TCGA patient cohorts, RNA activity of the "Positive regulation of CD4-positive, alpha-beta T cell activation" pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RCSD1, RCSD1_S179, and ARRB2, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Positive regulation of CD4-positive, alpha-beta T cell activation" activity versus RCSD1 in GBM (Pearson r = 0.76).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RCSD1 →	+0.626	+0.079	<.001	<.001	3	10
PDAC	RCSD1_S179 →	+0.865	+0.057	<.001	<.001	3	10
UCEC	ARRB2 →	+0.301	+0.046	.001	.002	3	10
BRCA	SAMSN1_S23 →	+1.026	+0.051	<.001	<.001	3	10
GBM	SASH3 →	+0.570	+0.086	<.001	<.001	3	10
OV	SEPTIN1 →	+0.888	+0.053	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000516 vs RCSD1 — GBM

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