"Positive regulation of CD4-positive, alpha-beta T cell activation"

Across TCGA cell cohorts, RNA activity of the "Positive regulation of CD4-positive, alpha-beta T cell activation" pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NFE2L3, IVNS1ABP, and ONECUT2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NFE2L3 grouped by "Positive regulation of CD4-positive, alpha-beta T cell activation"-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	NFE2L3 →	-1.734	-0.803	<.001	.002	3	4
SKIN	IVNS1ABP →	+0.707	+0.441	.001	.004	3	3
SKIN	ONECUT2 →	+0.506	+0.432	.001	.005	3	3
BONE	CAMK2G →	-0.861	-1.419	.007	.003	3	3
SKIN	BRINP2 →	-1.085	-0.611	<.001	.003	3	3
SKIN	ARNTL2 →	-1.415	-0.454	<.001	.003	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NFE2L3 by "Positive regulation of CD4-positive, alpha-beta T cell activation" activity — SKIN

Explore this box plot interactively →