"Positive regulation of CD4-positive, alpha-beta T cell activation"

Across TCGA cell cohorts, RNA activity of the "Positive regulation of CD4-positive, alpha-beta T cell activation" pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANXA1, SCPEP1, and GPR160, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Positive regulation of CD4-positive, alpha-beta T cell activation" activity versus ANXA1 in BREAST (Pearson r = 0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ANXA1 →	+3.302	+0.678	<.001	<.001	3	6
BREAST	SCPEP1 →	+1.279	+0.825	.007	.004	3	5
BREAST	GPR160 →	-2.013	-0.599	.004	.004	3	5
CNS	RELB →	+0.892	+0.149	.002	.008	3	4
CNS	TRIM22 →	+2.175	+0.213	.004	.002	3	4
UPPER_AERODIGESTIVE_TRACT	C1orf210 →	-0.978	-0.171	.004	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000516 vs ANXA1 — BREAST

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