"Negative regulation of CD4-positive, alpha-beta T cell activation"

Across TCGA patient cohorts, RNA activity of the "Negative regulation of CD4-positive, alpha-beta T cell activation" pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are WIPF1, MYO1F, and TBC1D2B, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Negative regulation of CD4-positive, alpha-beta T cell activation" activity versus WIPF1 in COAD (Pearson r = 0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	WIPF1 →	+0.387	+0.037	<.001	<.001	3	9
GBM	MYO1F →	+0.776	+0.107	<.001	<.001	3	9
GBM	TBC1D2B →	+0.400	+0.098	<.001	<.001	3	8
GBM	CD163 →	+1.164	+0.104	<.001	<.001	3	8
GBM	CNN2 →	+0.599	+0.065	<.001	<.001	3	8
GBM	DPYD →	+0.909	+0.088	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000515 vs WIPF1 — COAD

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