"Negative regulation of CD4-positive, alpha-beta T cell activation"

Across TCGA patient cohorts, RNA activity of the "Negative regulation of CD4-positive, alpha-beta T cell activation" pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SOD2, FPR1, and CSF3R, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Negative regulation of CD4-positive, alpha-beta T cell activation" activity versus SOD2 in GBM (Pearson r = 0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SOD2 →	+1.472	+0.767	<.001	<.001	3	5
OV	FPR1 →	+0.908	+0.226	.005	.004	2	6
GBM	CSF3R →	+1.103	+0.712	<.001	<.001	2	6
GBM	FCGR2A →	+1.220	+0.818	<.001	<.001	3	5
GBM	LILRB3 →	+0.836	+0.521	<.001	.005	3	5
GBM	MIR223HG →	+0.981	+0.734	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000515 vs SOD2 — GBM

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