"Negative regulation of CD4-positive, alpha-beta T cell activation"

Across TCGA cell cohorts, RNA activity of the "Negative regulation of CD4-positive, alpha-beta T cell activation" pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DUSP10, GLE1, and SNRPF, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DUSP10 grouped by "Negative regulation of CD4-positive, alpha-beta T cell activation"-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	DUSP10 →	-2.295	-1.084	.003	.001	3	5
SOFT_TISSUE	GLE1 →	-0.675	-1.457	.007	.004	3	4
LUNG_SCLC	SNRPF →	+0.454	+0.819	.001	.003	3	4
SKIN	NOSIP →	-0.628	-1.195	.008	<.001	2	4
SKIN	HTRA1 →	+1.912	+1.084	.009	<.001	3	3
OESOPHAGUS	HIBCH →	+1.126	+1.220	.002	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DUSP10 by "Negative regulation of CD4-positive, alpha-beta T cell activation" activity — SOFT_TISSUE

Explore this box plot interactively →