"Negative regulation of CD4-positive, alpha-beta T cell activation"

Across TCGA cell cohorts, RNA activity of the "Negative regulation of CD4-positive, alpha-beta T cell activation" pathway is significantly associated with the shRNA dependency of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAPK4, TRIM28, and ATP6V1A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MAPK4 grouped by "Negative regulation of CD4-positive, alpha-beta T cell activation"-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	MAPK4 →	-0.171	-0.128	.001	.009	3	5
BONE	TRIM28 →	-0.314	-0.114	.001	.005	3	4
LUNG_NSCLC_LUSC	ATP6V1A →	+0.544	+0.145	<.001	<.001	3	4
LUNG_NSCLC_LUSC	AKR7A3 →	-0.235	-0.108	.007	.006	2	5
LUNG_NSCLC_LUSC	VCX2 →	-0.290	-0.113	<.001	.002	3	4
LUNG_NSCLC_LUSC	FNBP1 →	+0.309	+0.140	.007	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MAPK4 by "Negative regulation of CD4-positive, alpha-beta T cell activation" activity — STOMACH

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