"Negative regulation of CD4-positive, alpha-beta T cell activation"

Across TCGA cell cohorts, RNA activity of the "Negative regulation of CD4-positive, alpha-beta T cell activation" pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATP8B3, ZEB1, and LGALS1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Negative regulation of CD4-positive, alpha-beta T cell activation" activity versus ATP8B3 in LUNG_NSCLC_LUAD (Pearson r = 0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	ATP8B3 →	+1.289	+0.215	.002	<.001	3	7
PANCREAS	ZEB1 →	+1.837	+0.314	<.001	.004	3	7
BLOOD_Lymphoma	LGALS1 →	+3.820	+0.269	<.001	<.001	3	7
BREAST	SACS →	+1.770	+0.279	.001	.009	3	6
BLOOD_Lymphoma	BCL7A →	-2.385	-0.208	.004	.001	3	6
LUNG_NSCLC_LUSC	PTPN18 →	+1.056	+0.430	.008	.009	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000515 vs ATP8B3 — LUNG_NSCLC_LUAD

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