"Regulation of CD4-positive, alpha-beta T cell activation"

Across TCGA patient cohorts, RNA activity of the "Regulation of CD4-positive, alpha-beta T cell activation" pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RCSD1, RCSD1_S351, and ARRB2, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Regulation of CD4-positive, alpha-beta T cell activation" activity versus RCSD1 in GBM (Pearson r = 0.79).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RCSD1 →	+0.648	+0.078	<.001	<.001	3	10
UCEC	RCSD1_S351 →	+0.694	+0.046	<.001	.004	3	10
COAD	ARRB2 →	+0.337	+0.022	.001	.004	3	10
GBM	SAMSN1 →	+0.718	+0.081	<.001	<.001	3	10
BRCA	SAMSN1_S23 →	+1.011	+0.050	<.001	<.001	3	10
GBM	SASH3 →	+0.587	+0.084	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000514 vs RCSD1 — GBM

Explore this scatter interactively →