"Regulation of CD4-positive, alpha-beta T cell activation"

Across TCGA cell cohorts, RNA activity of the "Regulation of CD4-positive, alpha-beta T cell activation" pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LGALS1, ATP8B3, and RAB25, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Regulation of CD4-positive, alpha-beta T cell activation" activity versus LGALS1 in LUNG_NSCLC_LUSC (Pearson r = 0.82).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	LGALS1 →	+6.590	+0.412	.001	.002	3	8
LUNG_NSCLC_LUSC	ATP8B3 →	+2.419	+0.388	<.001	<.001	3	8
LUNG_NSCLC_LUSC	RAB25 →	-6.213	-0.498	<.001	<.001	3	7
LUNG_NSCLC_LUSC	KDF1 →	-3.159	-0.425	<.001	.003	3	7
LUNG_NSCLC_LUSC	STX2 →	+2.090	+0.428	.001	<.001	3	7
LUNG_NSCLC_LUSC	ZEB1 →	+2.943	+0.388	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000514 vs LGALS1 — LUNG_NSCLC_LUSC

Explore this scatter interactively →