Positive regulation of dendritic cell chemotaxis

Across TCGA patient cohorts, RNA activity of the Positive regulation of dendritic cell chemotaxis pathway is significantly associated with the RNA expression of multiple genes, with the TGCT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TNFAIP8L2, FGR, and CYTH4, each associated with the pathway in up to 30 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of dendritic cell chemotaxis activity versus TNFAIP8L2 in TGCT (Pearson r = 0.71).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
TGCT	TNFAIP8L2 →	+1.563	+0.114	<.001	<.001	3	30
SCLC	FGR →	+2.000	+0.271	<.001	<.001	3	30
SCLC	CYTH4 →	+1.427	+0.263	<.001	<.001	3	29
THYM	CD3D →	+2.610	+0.119	<.001	<.001	3	29
THYM	CD7 →	+1.851	+0.109	<.001	<.001	3	29
LGG	LYL1 →	+1.229	+0.133	<.001	<.001	3	29

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000510 vs TNFAIP8L2 — TGCT

Explore this scatter interactively →