Positive regulation of dendritic cell chemotaxis

Across TCGA patient cohorts, RNA activity of the Positive regulation of dendritic cell chemotaxis pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD22, CD80, and FLT3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of dendritic cell chemotaxis activity versus CD22 in GBM (Pearson r = 0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CD22 →	+0.734	+0.180	.006	.003	3	4
GBM	CD80 →	+0.414	+0.149	<.001	.008	3	4
GBM	FLT3 →	+0.471	+0.234	.001	<.001	3	4
GBM	LINC00861 →	+0.270	+0.217	<.001	<.001	3	4
COAD	KPNA2 →	-0.372	-0.147	.001	<.001	3	4
LUAD	DEXI →	+0.360	+0.368	.003	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000510 vs CD22 — GBM

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