Regulation of dendritic cell chemotaxis

Across TCGA patient cohorts, RNA activity of the Regulation of dendritic cell chemotaxis pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DEXI, KPNA4P1, and P2RY8, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of dendritic cell chemotaxis activity versus DEXI in LUAD (Pearson r = 0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	DEXI →	+0.375	+0.408	.001	.004	3	4
HNSC	KPNA4P1 →	+0.358	+0.271	.001	.008	2	5
GBM	P2RY8 →	+0.914	+0.270	<.001	<.001	3	4
UCEC	IPCEF1 →	+0.654	+0.075	.004	.006	3	4
UCEC	CCDC113 →	+1.044	+0.131	<.001	<.001	3	4
UCEC	DNAH6 →	+0.723	+0.075	.005	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000508 vs DEXI — LUAD

Explore this scatter interactively →