Positive regulation of natural killer cell chemotaxis

Across TCGA cell cohorts, RNA activity of the Positive regulation of natural killer cell chemotaxis pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SEMA5A, MTIF3, and RP1L1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SEMA5A grouped by Positive regulation of natural killer cell chemotaxis-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SEMA5A →	+1.944	+1.146	.001	.002	3	4
LUNG_NSCLC_LUAD	MTIF3 →	+0.603	+0.773	.003	<.001	3	3
LUNG_NSCLC_LUAD	RP1L1 →	+0.248	+0.501	<.001	<.001	3	3
LUNG_NSCLC_LUAD	TDRD3 →	+0.474	+0.471	.006	.008	3	3
SOFT_TISSUE	MTMR6 →	+0.531	+0.955	.007	.006	3	3
SOFT_TISSUE	EFCAB6 →	+0.365	+1.690	.009	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SEMA5A by Positive regulation of natural killer cell chemotaxis activity — SKIN

Explore this box plot interactively →