Regulation of natural killer cell chemotaxis

Across TCGA cell cohorts, RNA activity of the Regulation of natural killer cell chemotaxis pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TSEN2, ATAD2, and GNPTAB, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TSEN2 grouped by Regulation of natural killer cell chemotaxis-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	TSEN2 →	+0.640	+0.958	.001	.007	3	4
KIDNEY	ATAD2 →	-1.428	-1.440	.002	.002	3	4
OVARY	GNPTAB →	+0.940	+1.395	<.001	.001	3	3
LUNG_NSCLC_LUSC	BRI3 →	+1.296	+1.272	.002	.009	3	3
LUNG_NSCLC_LUSC	MTBP →	-1.106	-1.355	.008	.009	3	3
SKIN	POLR1E →	-0.903	-1.118	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TSEN2 by Regulation of natural killer cell chemotaxis activity — STOMACH

Explore this box plot interactively →