Regulation of natural killer cell chemotaxis

Across TCGA cell cohorts, RNA activity of the Regulation of natural killer cell chemotaxis pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ABCA12, DNAI1, and ACP5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ABCA12 grouped by Regulation of natural killer cell chemotaxis-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	ABCA12 →	-0.198	-1.188	<.001	<.001	3	4
SOFT_TISSUE	DNAI1 →	+0.347	+2.117	.003	<.001	3	4
LIVER	ACP5 →	-0.244	-1.913	.001	.006	3	3
LIVER	TRPC3 →	+0.163	+1.552	.003	<.001	3	3
LIVER	CNGA3 →	+0.162	+1.649	.001	<.001	3	3
LIVER	NME6 →	-0.232	-1.489	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ABCA12 by Regulation of natural killer cell chemotaxis activity — SKIN

Explore this box plot interactively →