Positive regulation of hepatic stellate cell activation

Across TCGA patient cohorts, RNA activity of the Positive regulation of hepatic stellate cell activation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IGFBP7, LINC00922, and EVA1A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of hepatic stellate cell activation activity versus IGFBP7 in BRCA (Pearson r = 0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	IGFBP7 →	+1.005	+0.317	<.001	<.001	3	5
BRCA	LINC00922 →	+0.734	+0.261	<.001	<.001	3	5
BRCA	EVA1A →	+0.685	+0.338	<.001	.001	3	4
GBM	NPC2 →	+0.702	+0.563	.003	<.001	3	4
BRCA	FBLIM1 →	+0.818	+0.252	<.001	.001	3	4
BRCA	ACTG2 →	+1.525	+0.229	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000491 vs IGFBP7 — BRCA

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