Positive regulation of hepatic stellate cell activation

Across TCGA cell cohorts, RNA activity of the Positive regulation of hepatic stellate cell activation pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OPA1, CARS1, and UTP23, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, OPA1 grouped by Positive regulation of hepatic stellate cell activation-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	OPA1 →	-0.711	-1.549	<.001	<.001	3	5
LUNG_NSCLC_LUSC	CARS1 →	-1.383	-1.377	.006	.003	3	4
UPPER_AERODIGESTIVE_TRACT	UTP23 →	-1.416	-1.203	.008	.007	3	4
LIVER	ZNRD2 →	+0.978	+1.347	.004	.006	2	5
LUNG_NSCLC_LUSC	IL17RE →	+1.891	+1.601	<.001	.002	3	4
LUNG_NSCLC_LUSC	NSMAF →	-0.687	-2.006	.005	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

OPA1 by Positive regulation of hepatic stellate cell activation activity — URINARY_TRACT

Explore this box plot interactively →