Regulation of hepatic stellate cell activation

Across TCGA cell cohorts, RNA activity of the Regulation of hepatic stellate cell activation pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GMPR, RFTN1, and CD74, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of hepatic stellate cell activation activity versus GMPR in SKIN (Pearson r = 0.84).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	GMPR →	+4.285	+1.623	<.001	.001	3	3
BLOOD_Leukemia	RFTN1 →	-3.575	-1.763	.002	.001	3	3
SKIN	CD74 →	-8.056	-1.873	<.001	.002	3	3
SKIN	TLE4 →	-2.952	-1.765	.001	.002	3	3
SKIN	PPM1H →	+1.780	+2.074	<.001	<.001	3	3
SKIN	ACADS →	+1.169	+1.452	.005	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000489 vs GMPR — SKIN

Explore this scatter interactively →