Regulation of glycogen (starch) synthase activity

Across TCGA patient cohorts, RNA activity of the Regulation of glycogen (starch) synthase activity pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are THOC1, TIMM50, and TOP1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of glycogen (starch) synthase activity activity versus THOC1 in LUAD (Pearson r = 0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	THOC1 →	+0.152	+0.047	<.001	<.001	3	6
PDAC	TIMM50 →	+0.404	+0.060	<.001	<.001	3	5
LUAD	TOP1 →	+0.360	+0.054	<.001	.001	3	4
HNSC	HSPA12B →	-0.321	-0.065	<.001	<.001	3	4
HNSC	KANK3_S160 →	-0.591	-0.074	<.001	<.001	3	4
HNSC	MMRN2 →	-0.288	-0.068	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000465 vs THOC1 — LUAD

Explore this scatter interactively →