Regulation of glycogen (starch) synthase activity

Across TCGA patient cohorts, RNA activity of the Regulation of glycogen (starch) synthase activity pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FN1, UCK2, and CCN4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of glycogen (starch) synthase activity activity versus FN1 in LSCC (Pearson r = 0.16).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	FN1 →	+0.918	+0.187	<.001	<.001	3	5
CCRCC	UCK2 →	-0.237	-0.277	.006	.001	3	4
LSCC	CCN4 →	+0.658	+0.175	<.001	<.001	3	4
PDAC	MPP1 →	+0.257	+0.126	.001	.003	3	4
PDAC	FNDC1 →	+0.544	+0.123	.004	.003	3	4
LSCC	SERPINE1 →	+0.947	+0.181	.003	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000465 vs FN1 — LSCC

Explore this scatter interactively →