Regulation of glycogen (starch) synthase activity

Across TCGA cell cohorts, RNA activity of the Regulation of glycogen (starch) synthase activity pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAPGEF4, VIRMA, and PNPLA3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RAPGEF4 grouped by Regulation of glycogen (starch) synthase activity-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	RAPGEF4 →	+2.052	+1.804	.005	.001	3	5
LUNG_NSCLC_LUSC	VIRMA →	-0.536	-1.275	.009	.003	3	4
OVARY	PNPLA3 →	-1.634	-1.811	<.001	<.001	3	4
PANCREAS	DCAF13 →	-1.022	-1.373	<.001	.001	3	4
CNS	ACY1 →	+0.906	+0.945	.002	.001	3	4
UPPER_AERODIGESTIVE_TRACT	DEPP1 →	+2.773	+1.564	<.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RAPGEF4 by Regulation of glycogen (starch) synthase activity activity — BLOOD_Myeloma

Explore this box plot interactively →