Positive regulation of excitatory postsynaptic potential

Across TCGA patient cohorts, RNA activity of the Positive regulation of excitatory postsynaptic potential pathway is significantly associated with the RNA expression of multiple genes, with the LGG cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STX1A, DVL1, and AGAP3, each associated with the pathway in up to 21 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of excitatory postsynaptic potential activity versus STX1A in LGG (Pearson r = 0.82).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LGG	STX1A →	+1.907	+0.082	<.001	<.001	3	21
LAML	DVL1 →	+0.536	+0.049	.002	<.001	3	19
THYM	AGAP3 →	+0.807	+0.038	<.001	<.001	3	19
READ	MAPK8IP3 →	+0.914	+0.036	<.001	<.001	3	19
ESCA	GRIN2D →	+1.464	+0.041	<.001	<.001	3	19
THYM	JCHAIN →	-1.921	-0.029	<.001	<.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000463 vs STX1A — LGG

Explore this scatter interactively →