Positive regulation of excitatory postsynaptic potential

Across TCGA patient cohorts, RNA activity of the Positive regulation of excitatory postsynaptic potential pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are COL12A1, PLEC_S1888, and PLEC_S2039, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of excitatory postsynaptic potential activity versus COL12A1 in COAD (Pearson r = 0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	COL12A1 →	+0.638	+0.035	<.001	.002	3	6
BRCA	PLEC_S1888 →	+1.108	+0.054	<.001	<.001	3	5
BRCA	PLEC_S2039 →	+1.108	+0.054	<.001	<.001	3	5
LSCC	RPRD2_S614 →	-0.404	-0.043	.002	<.001	3	5
GBM	SMARCD2 →	-0.258	-0.080	.002	.002	3	5
OV	TFDP2_S24 →	-0.695	-0.049	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000463 vs COL12A1 — COAD

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