Positive regulation of excitatory postsynaptic potential

Across TCGA cell cohorts, RNA activity of the Positive regulation of excitatory postsynaptic potential pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STPG1, FAAH2, and SLC11A1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, STPG1 grouped by Positive regulation of excitatory postsynaptic potential-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	STPG1 →	-1.237	-1.358	.002	.004	3	4
LUNG_NSCLC_LUAD	FAAH2 →	+1.261	+0.883	.001	<.001	3	3
LUNG_NSCLC_LUAD	SLC11A1 →	+0.348	+0.950	.009	.001	3	3
LUNG_NSCLC_LUAD	MYBL1 →	-1.206	-0.655	.008	.005	3	3
SOFT_TISSUE	RPL35 →	+1.258	+1.157	.002	.003	3	3
SOFT_TISSUE	UPF2 →	-0.888	-1.148	<.001	.002	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

STPG1 by Positive regulation of excitatory postsynaptic potential activity — LUNG_NSCLC_LUSC

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