Positive regulation of excitatory postsynaptic potential

Across TCGA cell cohorts, RNA activity of the Positive regulation of excitatory postsynaptic potential pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KLK6, BAIAP2, and TMEM265, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of excitatory postsynaptic potential activity versus KLK6 in LUNG_NSCLC_LUAD (Pearson r = 0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	KLK6 →	+3.924	+1.455	.007	.005	3	5
LARGE_INTESTINE	BAIAP2 →	+1.713	+1.320	<.001	<.001	3	5
SOFT_TISSUE	TMEM265 →	+2.373	+1.619	<.001	.006	3	5
LUNG_NSCLC_LUSC	TINAGL1 →	+6.053	+1.472	.001	<.001	3	4
LUNG_NSCLC_LUSC	MSH5 →	-1.127	-1.507	.003	<.001	3	4
SOFT_TISSUE	EWSR1 →	-0.718	-1.404	.006	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000463 vs KLK6 — LUNG_NSCLC_LUAD

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