Regulation of monocyte extravasation

Across TCGA patient cohorts, RNA activity of the Regulation of monocyte extravasation pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLAC9, CSDC2, and FBXL7, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of monocyte extravasation activity versus PLAC9 in GBM (Pearson r = 0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PLAC9 →	+0.370	+0.670	.003	<.001	3	4
GBM	CSDC2 →	+0.873	+0.851	.001	<.001	3	3
LSCC	FBXL7 →	+0.413	+0.143	.006	.004	3	3
PDAC	NRP2 →	-0.527	-0.349	<.001	.004	3	3
PDAC	PAFAH1B1P2 →	-0.507	-0.430	.001	<.001	3	3
PDAC	SPDL1 →	-0.319	-0.396	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000437 vs PLAC9 — GBM

Explore this scatter interactively →