Regulation of monocyte extravasation

Across TCGA cell cohorts, RNA activity of the Regulation of monocyte extravasation pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CHPF, NPIPB5, and GRK4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CHPF grouped by Regulation of monocyte extravasation-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	CHPF →	+1.104	+0.720	.009	.009	3	5
KIDNEY	NPIPB5 →	-1.461	-1.224	<.001	<.001	3	4
PANCREAS	GRK4 →	+0.557	+0.768	.004	.004	3	4
PANCREAS	MAP4 →	+0.713	+0.793	.006	.007	3	4
PANCREAS	PLPP1 →	+1.089	+0.770	.003	<.001	3	4
LUNG_SCLC	LBR →	-0.981	-1.379	.002	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CHPF by Regulation of monocyte extravasation activity — CNS

Explore this box plot interactively →