Positive regulation of apoptotic cell clearance

Across TCGA cell cohorts, RNA activity of the Positive regulation of apoptotic cell clearance pathway is significantly associated with the drug response of multiple features, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are Tamoxifen, BAY-HDAC11_4, and Temozolomide, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, Tamoxifen grouped by Positive regulation of apoptotic cell clearance-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Tamoxifen →	+0.340	+1.644	.036	.016	2	2
BLOOD_Lymphoma	BAY-HDAC11_4 →	+1.199	+1.809	.032	.004	2	1
BLOOD_Lymphoma	Temozolomide →	+1.225	+1.809	.035	.004	2	1
BLOOD_Lymphoma	AZD7969 →	+0.748	+1.694	.027	.002	2	1
BLOOD_Lymphoma	Pevonedistat →	+1.080	+1.809	.026	.004	2	1
BLOOD_Lymphoma	EPZ5676 →	+0.338	+1.694	.007	.002	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Tamoxifen by Positive regulation of apoptotic cell clearance activity — BLOOD_Lymphoma

Explore this box plot interactively →