Regulation of apoptotic cell clearance

Across TCGA cell cohorts, RNA activity of the Regulation of apoptotic cell clearance pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DIPK1B, CBX2, and TACO1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DIPK1B grouped by Regulation of apoptotic cell clearance-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	DIPK1B →	+1.807	+1.382	<.001	<.001	3	5
PANCREAS	CBX2 →	+1.201	+0.917	.002	.002	3	5
SOFT_TISSUE	TACO1 →	+0.637	+1.099	.001	.003	3	4
LUNG_SCLC	GTPBP8 →	-0.619	-0.897	.008	.005	3	4
LUNG_SCLC	OCLN →	+1.385	+1.040	.006	.007	3	4
BLOOD_Lymphoma	STRADB →	-2.506	-1.743	.009	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DIPK1B by Regulation of apoptotic cell clearance activity — PANCREAS

Explore this box plot interactively →