Regulation of apoptotic cell clearance

Across TCGA cell cohorts, RNA activity of the Regulation of apoptotic cell clearance pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TGM2, TNFAIP1, and MARCHF8, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of apoptotic cell clearance activity versus TGM2 in OESOPHAGUS (Pearson r = 0.72).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	TGM2 →	+4.538	+0.251	.008	.009	3	5
OESOPHAGUS	TNFAIP1 →	+1.029	+0.297	.008	<.001	3	5
BREAST	MARCHF8 →	+1.184	+0.268	.004	.001	3	4
BLOOD_Lymphoma	PLEKHA2 →	+2.625	+0.231	<.001	.001	3	4
BLOOD_Lymphoma	MRAS →	-2.931	-0.276	.001	.001	3	4
BLOOD_Lymphoma	CDRT1 →	-0.758	-0.251	.007	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000425 vs TGM2 — OESOPHAGUS

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