Regulation of T cell extravasation

Across TCGA patient cohorts, RNA activity of the Regulation of T cell extravasation pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SPN, DEF6, and CD4, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of T cell extravasation activity versus SPN in OV (Pearson r = 0.52).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SPN →	+0.972	+0.080	<.001	<.001	3	9
BRCA	DEF6 →	+0.630	+0.106	<.001	<.001	3	9
GBM	CD4 →	+0.584	+0.097	<.001	<.001	3	8
BRCA	GIMAP1 →	+0.695	+0.092	<.001	<.001	3	8
LSCC	LAT_S224 →	+0.949	+0.093	<.001	<.001	3	8
GBM	SAMHD1 →	+0.389	+0.077	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000407 vs SPN — OV

Explore this scatter interactively →