Regulation of T cell extravasation

Across TCGA patient cohorts, RNA activity of the Regulation of T cell extravasation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RIPK3, PLS3, and BAG5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of T cell extravasation activity versus RIPK3 in BRCA (Pearson r = 0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RIPK3 →	+0.723	+0.532	<.001	<.001	3	5
LUAD	PLS3 →	+0.739	+0.253	<.001	.001	3	3
LUAD	BAG5 →	+0.291	+0.326	.005	.002	3	3
LUAD	LINC01137 →	+0.454	+0.198	<.001	.004	3	3
LUAD	MIR4319 →	-0.687	-0.233	.004	.004	3	3
COAD	ENTPD5 →	+0.528	+0.420	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000407 vs RIPK3 — BRCA

Explore this scatter interactively →