Regulation of T cell extravasation

Across TCGA cell cohorts, RNA activity of the Regulation of T cell extravasation pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLGRKT, TNIP1, and IRAK2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PLGRKT grouped by Regulation of T cell extravasation-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	PLGRKT →	+1.161	+1.097	.001	.002	3	4
LIVER	TNIP1 →	+1.519	+1.106	<.001	.002	3	4
BLOOD_Lymphoma	IRAK2 →	+2.324	+1.775	<.001	<.001	3	4
LUNG_NSCLC_LUAD	PRR36 →	-1.280	-0.932	<.001	.001	3	4
LUNG_NSCLC_LUAD	PHRF1 →	-0.443	-0.731	.008	.005	3	4
OVARY	PLAGL2 →	-0.979	-1.135	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PLGRKT by Regulation of T cell extravasation activity — LIVER

Explore this box plot interactively →