Positive regulation of T cell migration

Across TCGA cell cohorts, RNA activity of the Positive regulation of T cell migration pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARMH4, TENM4, and SUMF1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of T cell migration activity versus ARMH4 in KIDNEY (Pearson r = 0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	ARMH4 →	+1.072	+0.247	.004	.003	3	5
LUNG_SCLC	TENM4 →	+1.576	+0.158	.008	.007	2	6
KIDNEY	SUMF1 →	+1.444	+0.302	.004	.008	3	4
OVARY	NRDE2 →	-0.913	-0.316	<.001	.002	3	4
OVARY	PRPF4 →	-0.905	-0.357	<.001	<.001	3	4
KIDNEY	TUBB2B →	+3.597	+0.338	.006	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000406 vs ARMH4 — KIDNEY

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