Negative regulation of T cell migration

Across TCGA cell cohorts, RNA activity of the Negative regulation of T cell migration pathway is significantly associated with the shRNA dependency of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MED4, TIPARP, and MIDEAS, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MED4 grouped by Negative regulation of T cell migration-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	MED4 →	-0.268	-1.631	.002	<.001	2	5
LIVER	TIPARP →	-0.301	-1.467	.001	<.001	3	4
CNS	MIDEAS →	-0.275	-1.722	.008	<.001	3	4
OESOPHAGUS	PCDHA9 →	+0.224	+1.580	.004	<.001	3	4
LIVER	HCAR2 →	+0.215	+1.548	.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	PAK2 →	+0.302	+1.408	.008	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MED4 by Negative regulation of T cell migration activity — URINARY_TRACT

Explore this box plot interactively →