Negative regulation of T cell migration

Across TCGA cell cohorts, RNA activity of the Negative regulation of T cell migration pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLEK2, MON1B, and CSPP1, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of T cell migration activity versus PLEK2 in BLOOD_Lymphoma (Pearson r = 0.80).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	PLEK2 →	+0.206	+0.566	.007	.005	3	1
BLOOD_Lymphoma	MON1B →	+0.747	+0.420	<.001	.005	3	1
BLOOD_Lymphoma	CSPP1 →	+1.099	+0.449	.002	.008	3	1
BLOOD_Lymphoma	GDAP1 →	+1.231	+0.420	.009	.005	3	1
BLOOD_Lymphoma	RIC1 →	+1.143	+0.420	.009	.005	3	1
BLOOD_Lymphoma	INTS2 →	+0.641	+0.420	.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000405 vs PLEK2 — BLOOD_Lymphoma

Explore this scatter interactively →