Negative regulation of T cell migration

Across TCGA cell cohorts, RNA activity of the Negative regulation of T cell migration pathway is significantly associated with the drug response of multiple features, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are Camptothecin, Olaparib, and Irinotecan, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, Camptothecin grouped by Negative regulation of T cell migration-low versus -high activity in BLOOD_Leukemia.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Camptothecin →	-0.675	-0.362	.004	.012	2	2
BLOOD_Leukemia	Olaparib →	-0.656	-0.362	.036	.012	2	2
BLOOD_Leukemia	Irinotecan →	-0.541	-0.362	.017	.012	2	2
BLOOD_Leukemia	Oxaliplatin →	-0.394	-0.316	.046	.017	2	2
BLOOD_Leukemia	Gemcitabine →	-1.691	-0.362	.004	.012	2	2
BLOOD_Leukemia	PFI3 →	-0.746	-0.362	<.001	.012	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Camptothecin by Negative regulation of T cell migration activity — BLOOD_Leukemia

Explore this box plot interactively →