Regulation of T cell migration

Across TCGA patient cohorts, RNA activity of the Regulation of T cell migration pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TAGAP, CASS4, and CYTH4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of T cell migration activity versus TAGAP in HNSC (Pearson r = 0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	TAGAP →	+0.783	+0.223	.008	.002	3	6
LSCC	CASS4 →	+0.555	+0.189	<.001	.004	3	6
HNSC	CYTH4 →	+0.831	+0.240	.001	<.001	3	6
BRCA	ARHGAP9 →	+0.784	+0.293	<.001	<.001	2	6
HNSC	CD96 →	+0.797	+0.229	.006	<.001	3	5
BRCA	JAML →	+0.768	+0.227	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000404 vs TAGAP — HNSC

Explore this scatter interactively →