Regulation of T cell migration

Across TCGA cell cohorts, RNA activity of the Regulation of T cell migration pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PCLO, PLK2, and TIAL1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PCLO grouped by Regulation of T cell migration-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	PCLO →	-0.901	-1.237	.002	<.001	3	6
LIVER	PLK2 →	+3.761	+1.563	.001	<.001	3	5
SOFT_TISSUE	TIAL1 →	-0.361	-0.956	.004	.003	3	4
BONE	ARNT2 →	+2.846	+1.469	.001	.005	3	4
KIDNEY	NCOR1 →	-0.892	-1.356	.008	<.001	3	4
KIDNEY	ZNF202 →	-0.857	-1.130	.007	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PCLO by Regulation of T cell migration activity — OVARY

Explore this box plot interactively →