Regulation of T cell migration

Across TCGA cell cohorts, RNA activity of the Regulation of T cell migration pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TENM4, MRPL36, and TMEM260, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of T cell migration activity versus TENM4 in KIDNEY (Pearson r = 0.70).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	TENM4 →	+2.511	+0.252	<.001	.006	2	5
KIDNEY	MRPL36 →	-1.109	-0.319	.001	.008	3	4
OVARY	TMEM260 →	+0.726	+0.177	.001	.001	3	4
LUNG_SCLC	NAPB →	+1.547	+0.309	.001	<.001	3	4
KIDNEY	ARMH4 →	+1.040	+0.240	.006	.001	3	4
LUNG_SCLC	SFXN4 →	-0.992	-0.244	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000404 vs TENM4 — KIDNEY

Explore this scatter interactively →