Negative regulation of lymphocyte migration

Across TCGA cell cohorts, RNA activity of the Negative regulation of lymphocyte migration pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDC25A, DONSON, and DNAL4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CDC25A grouped by Negative regulation of lymphocyte migration-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	CDC25A →	-1.187	-1.526	<.001	<.001	3	5
LUNG_NSCLC_LUAD	DONSON →	-0.441	-0.704	.002	.001	3	4
PANCREAS	DNAL4 →	+1.092	+1.546	.002	<.001	3	4
SKIN	WASHC3 →	+0.558	+0.803	<.001	.005	3	4
LUNG_SCLC	LHPP →	-1.293	-1.008	<.001	.002	3	4
LUNG_SCLC	SYDE2 →	-0.778	-1.323	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CDC25A by Negative regulation of lymphocyte migration activity — LIVER

Explore this box plot interactively →