Regulation of lymphocyte migration

Across TCGA patient cohorts, RNA activity of the Regulation of lymphocyte migration pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RCSD1, SASH3, and SPN_S355, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of lymphocyte migration activity versus RCSD1 in OV (Pearson r = 0.45).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	RCSD1 →	+0.698	+0.065	<.001	<.001	3	10
OV	SASH3 →	+0.592	+0.068	<.001	<.001	3	10
PDAC	SPN_S355 →	+0.729	+0.048	<.001	<.001	3	10
HNSC	STK10 →	+0.447	+0.095	<.001	<.001	3	10
GBM	TBC1D2B →	+0.390	+0.089	<.001	<.001	3	10
GBM	THEMIS2 →	+0.592	+0.099	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000401 vs RCSD1 — OV

Explore this scatter interactively →