Regulation of lymphocyte migration

Across TCGA patient cohorts, RNA activity of the Regulation of lymphocyte migration pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are AKAP13_S2563, SASH3_S38, and APOBR, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of lymphocyte migration activity versus AKAP13_S2563 in LUAD (Pearson r = 0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	AKAP13_S2563 →	+0.746	+0.257	<.001	<.001	3	6
LSCC	SASH3_S38 →	+0.801	+0.162	<.001	<.001	3	5
OV	APOBR →	+0.539	+0.311	<.001	<.001	2	6
LSCC	MYO1F_S1023 →	+0.948	+0.168	<.001	<.001	3	5
OV	SPN →	+0.974	+0.336	<.001	<.001	3	5
OV	STK10_S514 →	+0.780	+0.192	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000401 vs AKAP13_S2563 — LUAD

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