Regulation of lymphocyte migration

Across TCGA cell cohorts, RNA activity of the Regulation of lymphocyte migration pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRKAR2A, MRPS22, and BANF1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of lymphocyte migration activity versus PRKAR2A in SOFT_TISSUE (Pearson r = -0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	PRKAR2A →	-1.570	-0.308	.005	<.001	3	5
OVARY	MRPS22 →	-0.608	-0.192	.002	.001	3	4
SOFT_TISSUE	BANF1 →	-0.790	-0.296	.001	.004	3	4
BLOOD_Lymphoma	MRPL36 →	-0.717	-0.235	.005	.001	3	4
BLOOD_Myeloma	GLO1 →	-1.371	-0.290	<.001	.001	3	4
LUNG_SCLC	SMOC2 →	+2.966	+0.273	.002	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000401 vs PRKAR2A — SOFT_TISSUE

Explore this scatter interactively →