Regulation of neutrophil extravasation

Across TCGA patient cohorts, RNA activity of the Regulation of neutrophil extravasation pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FUS, C1R, and GBE1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of neutrophil extravasation activity versus FUS in LSCC (Pearson r = -0.45).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	FUS →	-0.396	-0.083	<.001	<.001	3	7
GBM	C1R →	+0.580	+0.111	<.001	<.001	3	6
BRCA	GBE1 →	+0.303	+0.039	.004	.003	3	6
GBM	RCN1 →	+0.315	+0.092	.007	.003	3	6
COAD	MRPL10 →	-0.319	-0.044	.002	.005	3	6
LSCC	AHNAK_S570 →	+0.642	+0.062	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000389 vs FUS — LSCC

Explore this scatter interactively →