Regulation of neutrophil extravasation

Across TCGA cell cohorts, RNA activity of the Regulation of neutrophil extravasation pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KPNA5, E2F2, and RPRD1A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KPNA5 grouped by Regulation of neutrophil extravasation-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	KPNA5 →	+0.884	+1.328	.003	.001	3	5
PANCREAS	E2F2 →	+1.237	+1.387	<.001	.002	3	5
LIVER	RPRD1A →	+1.595	+1.902	.002	.001	3	4
CNS	TXNL4A →	+0.598	+0.886	<.001	.003	3	4
LUNG_NSCLC_LUSC	CAMSAP3 →	+1.526	+1.464	.007	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	NRARP →	+3.170	+1.346	<.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KPNA5 by Regulation of neutrophil extravasation activity — OVARY

Explore this box plot interactively →