Regulation of mesoderm development

Across TCGA patient cohorts, RNA activity of the Regulation of mesoderm development pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NT5C3B, OSER1, and RPL21P119, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of mesoderm development activity versus NT5C3B in HNSC (Pearson r = 0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	NT5C3B →	+0.661	+0.705	<.001	.005	3	4
BRCA	OSER1 →	+0.354	+0.481	.005	.003	3	4
BRCA	RPL21P119 →	+0.787	+0.660	.001	.001	3	4
PDAC	SHISAL2A →	-0.456	-0.343	.008	.001	3	3
PDAC	ITFG1-AS1 →	-0.391	-0.374	.006	<.001	3	3
CCRCC	PRPSAP2 →	+0.620	+0.540	.006	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000380 vs NT5C3B — HNSC

Explore this scatter interactively →